It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Unlike men, women will find stacking Anavar in an off-season bulking cycle to be very beneficial. Although it will not promote a lot of mass, because women are far more sensitive they can gain some nice, lean tissue with an extremely low dose. However, as is with men it will be the cutting period in-which they benefit the most. Stacking Anavar in a female cycle can be the answer to success for many women, as this can make the difference between an average physique and one that is superb. Of course, it must be noted, although this steroid carries a low rate of virilization some women will fall prey due to genetic predisposition. If doses get too high, problems are almost guaranteed to occur, but regardless of where your dose falls, if you fall prey to problems you must necessarily discontinue use immediately to ensure the problems do not become permanent. Women who do this will find the problems fade away, but for the vast majority of women who supplement responsibly they will be fine.
It is during a cutting phase that males will benefit the most from being on an Anavar cycle because of the simple fact that it allows them to have a much harder and shredded physique. Anavar is one of those anabolic steroids that is widely used only during the contest preparation phase for a show. Anavar contains an Oxandrolone hormone which means that muscle tissue can be preserved and it increases metabolic activity which would promote fat burning. It is the perfect cycle to do during a cutting period as you are able to preserve the muscle you’ve put on in the off-season and get rid of the fat surrounding it.